Inline purification in continuous flow synthesis – opportunities and challenges


Beilstein J. Org. Chem. 2022, 18, 1720–1740
DOI: 10.3762/bjoc.18.182
García-Lacuna J, Baumann M*.

Di Filippo, M. and Baumann M., Continuous Flow Synthesis of Anticancer Drugs, Molecules 202126, 6992.
DOI: doi.org/10.3390/molecules26226992

Bonner, A., Loftus, A., Padgham, A.C. and Baumann M., Forgotten and forbidden chemical reactions revitalised through continuous flow technology, Org. Biomol. Chem., 202119, 7737-7753. DOI: 10.1039/D1OB01452H 

Baumann, M., Moody, T. S., Smyth, M. and Wharry, S., Evaluating the Green Credentials of Flow Chemistry towards Industrial Applications, Synthesis2021, 53, 3963-3976. DOI: 10.1055/a-1541-1761 

Donnelly, K. and Baumann, M., Scalability of photochemical reactions in continuous flow mode J. Flow Chem., 2021, 11, 223–241. DOI: 10.1007/s41981-021-00168-z 

Leslie, A., Joseph, A. M., Baumann, M., Functional Group Interconversion Reactions in Continuous Flow Reactors  Current Organic Chemistry, 2021, 25, 2217-2231.
DOI: 10.2174/1385272825666210610154414 

Di Filippo, M., Bracken, C., Baumann, M., Continuous Flow Photochemistry For The Preparation Of Bioactive Molecules, Molecules, 2020, 25, 356. DOI:10.3390/molecules25020356

Baumann, M., Moody, T.S., Smyth, M. and Wharry, S., A Perspective on Continuous Flow Chemistry in the Pharmaceutical Industry, Organic Process Research & Development, 2020, 24, 10, 1802–1813. DOI: doi.org/10.1021/acs.oprd.9b00524

Baumann, M., Moody, T.S., Smyth, M. and Wharry, S., Overcoming the Hurdles and Challenges Associated with Developing Continuous Industrial Processes
European Journal of Organic Chemistry, 2020, 48, 7398–7406, DOI: 10.1002/ejoc.202001278

Baumann, M., Integrating continuous flow synthesis with in-line analysis and data generation, Organic and Biomolecular Chemistry, 2018, 16, 5946-5954. DOI: 10.1039/c8ob01437j