Forbidden Chemistry

Flow chemsitry can enable the use highyl reactive intermediates. The spatiotemporal relationship between molecules within flow reactors prevent the accumulation of dangerous species. This inherent trait of flow processes can enable the safe large scale applications of such dangerous species. Furthermore the additional casing of flow reactors allow for the controlled introduction of high temperature and high pressure processes. These combined factors give access to synthethic routes, which prior to the application of flow chemsitry would be deemed too dangerous.

Development of a telescoped flow process for the safe and effective generation of propargylic amines
In this paper you can read how flow chemistry enabled intermediate azides, which were rapidly consumed upon formation in a telescoped flow process. This afforded a safe and effective route twoards proparglyic amines.
Development of a Continuous Photochemical Benzyne-Forming Process
In this paper you can read how benzyne’s could be both safely and efficently exploited with a safe and controlled gaseous release in a flow process.
A continuous flow synthesis of [1.1.1]propellane and bicyclo[1.1.1]pentane derivatives

In this paper you can read how a cryogenic flow reactor allowed for the safe utility of MeLi for the efficent generation of [1.1.1] propellane intermediates and their photochemical functionalisation.