Flow chemsitry can enable the use highyl reactive intermediates. The spatiotemporal relationship between molecules within flow reactors prevent the accumulation of dangerous species. This inherent trait of flow processes can enable the safe large scale applications of such dangerous species. Furthermore the additional casing of flow reactors allow for the controlled introduction of high temperature and high pressure processes. These combined factors give access to synthethic routes, which prior to the application of flow chemsitry would be deemed too dangerous.