2022-2018 Publications

Inline purification in continuous flow synthesis – opportunities and challenges

Jorge García-Lacuna, Marcus Baumann Beilstein J. Org. Chem. 2022, 18, 1720–1740
DOI: 10.3762/bjoc.18.182

Consecutive photochemical reactions enabled by
a dual flow reactor coil strategy

Ruairi Crawford, Mara Di Filippo, Duncan Guthrie, Marcus Baumann*. Chem. Commun., 2022, 58, 13274.
DOI: 10.1039/d2cc05601a

Synthesis and biological evaluation of fluoro-substituted cationic and neutral antibiotic NHC* silver derivatives of SBC3

Zoe Beato, Brad Ryan, Helge Müller-Bunz, Marcus Baumann*, Matthias Tacke. J. Organomet. Chem. 2022, 976, 122436,
DOI: doi.org/10.1016/j.jorganochem/2022.122436

Flow synthesis of oxadiazoles coupled with sequential in-line extraction and chromatography

Kian Donnelly and Marcus Baumann.
Beilstein J. Org. Chem2022, 18, 232–239,
DOI: doi.org/10.3762/bjoc.18.27

Protein domain-based prediction of drug/compound–target interactions and experimental validation on LIM kinases

Tunca Doğan, Ece Akhan Güzelcan, Marcus Baumann, Altay Koyas, Heval Atas, Ian R. Baxendale, Maria Martin, Rengul Cetin-Atalay.
PLoS Computational Biology 202117, 11, DOI: doi.org/10.1371/journal.pcbi.1009171

Continuous Flow Synthesis of Anticancer Drugs

Mara Di Filippo and Marcus Baumann.
Molecules 202126, 6992, DOI: doi.org/10.3390/molecules26226992

Synthesis of 2H-indazoles via the Cadogan reaction in batch and flow mode

Matilda Duffy, Mara Di Filippo and Marcus Baumann. Tetrahedron Lett., 2021, 86, 153522, DOI: 10.1016/j.tetlet.2021.153522

Interrupted Curtius Rearrangements of Quaternary Proline Derivatives: A Flow Route to Acyclic Ketones and Unsaturated Pyrrolidines

Marcus Baumann, Thomas S. Moody, Megan Smyth, and Scott Wharry. J. Org. Chem., 2021, 86, 20, 14199–14206, DOI: 10.1021/acs.joc.1c01133 

Highlighted by SynFacts: Synfacts 2021, 17, 1295

Scalability of photochemical reactions in continuous flow mode

Kian Donnelly and Marcus Baumann Journal of Flow Chemistry, 2021, 11, 223–241,
DOI: 10.1007/s41981-021-00168-z

Forgotten and forbidden chemical reactions revitalised through continuous flow technology

Arlene Bonner, Aisling Loftus, Alex C. Padgham and Marcus Baumann. Org. Biomol. Chem., 2021, 86, 20, 14199–14206 DOI: 10.1039/D1OB01452H

Discovery of a photochemical cascade process by flow-based interception of isomerising alkenes

Mara Di Filippo, Cristina Trujillo, Goar Sánchez-Sanz, Andrei S. Batsanov and Marcus Baumann. Chem. Sci.202112, 9895-9901, DOI:  10.1039/D1SC02879K  

A continuous flow synthesis of [1.1.1]propellane and bicyclo[1.1.1]pentane derivatives

Kian Donnelly and Marcus Baumann.
Chem. Commun.2021, 57, 2871-2874 DOI: doi.org/10.1039/D0CC08124H

Highlighted by SynFacts: Synfacts 2021, 17, 0715

Coupling biocatalysis with high-energy flow reactions for the synthesis of carbamates and β-amino acid derivatives

Alexander Leslie, Thomas S. Moody, Megan Smyth, Scott Wharry and Marcus Baumann. Beilstein J. Org. Chem., 2021, 17, 379–384 

Development of a Continuous Photochemical Benzyne-Forming Process

Cormac Bracken, Andrei S. Batsanov and Marcus Baumann.
SynOpen, 2021, 5, 1, 29-35, DOI: 10.1055/s-0040-1706016

Continuous flow synthesis and antimicrobial evaluation of NHC* silver carboxylate derivatives of SBC3 in vitro and in vivo

Cillian O’Beirne, Magdalena E Piatek, Jen Fossen, Helge  Müller-Bunz, David R Andes, Kevin Kavanagh, Siddappa A Patil, Marcus Baumann and Matthias Tacke Metallomics, 2021, 2, 13, mfaa011,

DOI: 10.1093/mtomcs/mfaa011

Tandem Continuous Flow Curtius Rearrangement and Subsequent Enzyme-Mediated Impurity Tagging

Marcus Baumann, Alexander Leslie, Thomas S. Moody, Megan Smyth* and Scott Wharry.
Organic Process Research & Development, 2021, 25, 3, 452–456 DOI: doi.org/10.1021/acs.oprd.0c00420

Functional Group Interconversion Reactions in Continuous Flow Reactors 

Alexander Leslie, Angel Maria Joseph and Marcus Baumann*.
Current Organic Chemistry, 2021, 25, 19, 2217 – 2231, DOI: 10.2174/1385272825666210610154414 

A Scalable Continuous Photochemical Process for the Generation of Aminopropylsulfones

Mara Di Filippo, Stefano Bonciolini and Marcus Baumann.
Organic & Biomolecular Chemistry, 2020, 18, 9428-9432.
DOI: 10.1039/D0OB01801E

Overcoming the Hurdles and Challenges Associated with Developing Continuous Industrial Processes Marcus Baumann, Thomas S. Moody, Megan Smyth and Scott Wharry.
European Journal of Organic Chemistry202048, 7398–7406, DOI: 10.1002/ejoc.202001278

Continuous Flow Synthesis of Quinolines via a Scalable Tandem Photoisomerization-Cyclization Process Mara Di Filippo and Marcus Baumann.
European Journal of Organic Chemistry, 2020, 39, 6199-6211, DOI: 10.1002/ejoc.202000957

Highlighted by SynFactsSynfacts 2021, 17, 117

Continuous Flow Photochemistry For The Preparation Of Bioactive Molecules

Mara Di Filippo, Cormac Bracken and Marcus Baumann.
Molecules2020, 25, 356, DOI:10.3390/molecules25020356

A Perspective on Continuous Flow Chemistry in the Pharmaceutical Industry

Marcus Baumann, Thomas S. Moody, Megan Smyth and Scott Wharry.
Organic Process Research & Development, 202024, 10, 1802–1813, DOI: doi.org/10.1021/acs.oprd.9b00524

Development of a continuous flow photoisomerization reaction converting isoxazoles into diverse oxazole products

Cormac Bracken and Marcus Baumann.
Journal of Organic Chemistry, 2020, 85, 4, 2607–2617, DOI: 10.1021/acs.joc.9b03399

Development of a telescoped flow process for the safe and effective generation of propargylic amines

Kian Donnelly, Huan Zhang and Marcus Baumann
Molecules, 201924, 20, 3658, DOI: 10.3390/molecules24203658

Synthesis of new derivatives of boehmeriasin A and their biological evaluation in liver cancer

Ece Akhan Güzelcan, Ian R. Bazendale, Rengul Cetin-Atalay and Marcus Baumann.
European Journal of Medicinal Chemistry, 2019, 166, 243-255, DOI: 10.1016/j.ejmech.2019.01.056

Integrating reactive distillation with continuous flow processing

Marcus Baumann
Reaction Chemistry and Engineering, 2019, 4, 2, 368-371, DOI: 10.1039/c8re00217g

Integrating continuous flow synthesis with in-line analysis and data generation

Marcus Baumann
Organic and Biomolecular Chemistry, 2018, 16, 5946-5954, DOI: 10.1039/c8ob01437j