Inline purification in continuous flow synthesis – opportunities and challenges
Jorge García-Lacuna, Marcus Baumann Beilstein J. Org. Chem. 2022, 18, 1720–1740
Consecutive photochemical reactions enabled by
a dual flow reactor coil strategy
Ruairi Crawford, Mara Di Filippo, Duncan Guthrie, Marcus Baumann*. Chem. Commun., 2022, 58, 13274.
Synthesis and biological evaluation of fluoro-substituted cationic and neutral antibiotic NHC* silver derivatives of SBC3
Zoe Beato, Brad Ryan, Helge Müller-Bunz, Marcus Baumann*, Matthias Tacke. J. Organomet. Chem. 2022, 976, 122436,
Continuous Flow Technology as an Enabler for Innovative Transformations Exploiting Carbenes, Nitrenes, and Benzynes
Kian Donnelly and Marcus Baumann. J. Org. Chem. 2022, 87, 13, 8279–8288,
Flow synthesis of oxadiazoles coupled with sequential in-line extraction and chromatography
Kian Donnelly and Marcus Baumann.
Beilstein J. Org. Chem. 2022, 18, 232–239,
Protein domain-based prediction of drug/compound–target interactions and experimental validation on LIM kinases
Tunca Doğan, Ece Akhan Güzelcan, Marcus Baumann, Altay Koyas, Heval Atas, Ian R. Baxendale, Maria Martin, Rengul Cetin-Atalay.
PLoS Computational Biology 2021, 17, 11, DOI: doi.org/10.1371/journal.pcbi.1009171
Continuous Flow Synthesis of Anticancer Drugs
Mara Di Filippo and Marcus Baumann.
Molecules 2021, 26, 6992, DOI: doi.org/10.3390/molecules26226992
Synthesis of 2H-indazoles via the Cadogan reaction in batch and flow mode
Matilda Duffy, Mara Di Filippo and Marcus Baumann. Tetrahedron Lett., 2021, 86, 153522, DOI: 10.1016/j.tetlet.2021.153522
Interrupted Curtius Rearrangements of Quaternary Proline Derivatives: A Flow Route to Acyclic Ketones and Unsaturated Pyrrolidines
Marcus Baumann, Thomas S. Moody, Megan Smyth, and Scott Wharry. J. Org. Chem., 2021, 86, 20, 14199–14206, DOI: 10.1021/acs.joc.1c01133
Highlighted by SynFacts: Synfacts 2021, 17, 1295
Scalability of photochemical reactions in continuous flow mode
Kian Donnelly and Marcus Baumann Journal of Flow Chemistry, 2021, 11, 223–241,
Forgotten and forbidden chemical reactions revitalised through continuous flow technology
Arlene Bonner, Aisling Loftus, Alex C. Padgham and Marcus Baumann. Org. Biomol. Chem., 2021, 86, 20, 14199–14206 DOI: 10.1039/D1OB01452H
Discovery of a photochemical cascade process by flow-based interception of isomerising alkenes
Mara Di Filippo, Cristina Trujillo, Goar Sánchez-Sanz, Andrei S. Batsanov and Marcus Baumann. Chem. Sci., 2021, 12, 9895-9901, DOI: 10.1039/D1SC02879K
A continuous flow synthesis of [1.1.1]propellane and bicyclo[1.1.1]pentane derivatives
Kian Donnelly and Marcus Baumann.
Chem. Commun., 2021, 57, 2871-2874 DOI: doi.org/10.1039/D0CC08124H
Highlighted by SynFacts: Synfacts 2021, 17, 0715
Coupling biocatalysis with high-energy flow reactions for the synthesis of carbamates and β-amino acid derivatives
Alexander Leslie, Thomas S. Moody, Megan Smyth, Scott Wharry and Marcus Baumann. Beilstein J. Org. Chem., 2021, 17, 379–384
Development of a Continuous Photochemical Benzyne-Forming Process
Cormac Bracken, Andrei S. Batsanov and Marcus Baumann.
SynOpen, 2021, 5, 1, 29-35, DOI: 10.1055/s-0040-1706016
Continuous flow synthesis and antimicrobial evaluation of NHC* silver carboxylate derivatives of SBC3 in vitro and in vivo
Cillian O’Beirne, Magdalena E Piatek, Jen Fossen, Helge Müller-Bunz, David R Andes, Kevin Kavanagh, Siddappa A Patil, Marcus Baumann and Matthias Tacke Metallomics, 2021, 2, 13, mfaa011,
Tandem Continuous Flow Curtius Rearrangement and Subsequent Enzyme-Mediated Impurity Tagging
Marcus Baumann, Alexander Leslie, Thomas S. Moody, Megan Smyth* and Scott Wharry.
Organic Process Research & Development, 2021, 25, 3, 452–456 DOI: doi.org/10.1021/acs.oprd.0c00420
Functional Group Interconversion Reactions in Continuous Flow Reactors
Alexander Leslie, Angel Maria Joseph and Marcus Baumann*.
Current Organic Chemistry, 2021, 25, 19, 2217 – 2231, DOI: 10.2174/1385272825666210610154414
A Scalable Continuous Photochemical Process for the Generation of Aminopropylsulfones
Mara Di Filippo, Stefano Bonciolini and Marcus Baumann.
Organic & Biomolecular Chemistry, 2020, 18, 9428-9432.
Overcoming the Hurdles and Challenges Associated with Developing Continuous Industrial Processes Marcus Baumann, Thomas S. Moody, Megan Smyth and Scott Wharry.
European Journal of Organic Chemistry, 2020, 48, 7398–7406, DOI: 10.1002/ejoc.202001278
Continuous Flow Synthesis of Quinolines via a Scalable Tandem Photoisomerization-Cyclization Process Mara Di Filippo and Marcus Baumann.
European Journal of Organic Chemistry, 2020, 39, 6199-6211, DOI: 10.1002/ejoc.202000957
Highlighted by SynFacts: Synfacts 2021, 17, 117
Continuous Flow Photochemistry For The Preparation Of Bioactive Molecules
Mara Di Filippo, Cormac Bracken and Marcus Baumann.
Molecules, 2020, 25, 356, DOI:10.3390/molecules25020356
A Perspective on Continuous Flow Chemistry in the Pharmaceutical Industry
Marcus Baumann, Thomas S. Moody, Megan Smyth and Scott Wharry.
Organic Process Research & Development, 2020, 24, 10, 1802–1813, DOI: doi.org/10.1021/acs.oprd.9b00524
Development of a continuous flow photoisomerization reaction converting isoxazoles into diverse oxazole products
Cormac Bracken and Marcus Baumann.
Journal of Organic Chemistry, 2020, 85, 4, 2607–2617, DOI: 10.1021/acs.joc.9b03399
Synthesis of Bioderived Cinnolines and Their Flow-Based Conversion into 1,4-Dihydrocinnoline Derivatives
Jonathan Devlin, Richard Clogher and Marcus Baumann.
Synlett, 2020, 31, 5, 487-491, DOI:10.1055/s-0039-1690752
Development of a telescoped flow process for the safe and effective generation of propargylic amines
Kian Donnelly, Huan Zhang and Marcus Baumann
Molecules, 2019, 24, 20, 3658, DOI: 10.3390/molecules24203658
Synthesis of new derivatives of boehmeriasin A and their biological evaluation in liver cancer
Ece Akhan Güzelcan, Ian R. Bazendale, Rengul Cetin-Atalay and Marcus Baumann.
European Journal of Medicinal Chemistry, 2019, 166, 243-255, DOI: 10.1016/j.ejmech.2019.01.056
Integrating reactive distillation with continuous flow processing
Reaction Chemistry and Engineering, 2019, 4, 2, 368-371, DOI: 10.1039/c8re00217g
Integrating continuous flow synthesis with in-line analysis and data generation
Organic and Biomolecular Chemistry, 2018, 16, 5946-5954, DOI: 10.1039/c8ob01437j