Baumann Research Group

Inline purification in continuous flow synthesis – opportunities and challenges

Jorge García-Lacuna, Marcus Baumann Beilstein J. Org. Chem. 2022, 18, 1720–1740
DOI: 10.3762/bjoc.18.182

Consecutive photochemical reactions enabled by
a dual flow reactor coil strategy

Ruairi Crawford, Mara Di Filippo, Duncan Guthrie, Marcus Baumann*. Chem. Commun., 2022, 58, 13274.
DOI: 10.1039/d2cc05601a

Synthesis and biological evaluation of fluoro-substituted cationic and neutral antibiotic NHC* silver derivatives of SBC3

Zoe Beato, Brad Ryan, Helge Müller-Bunz, Marcus Baumann*, Matthias Tacke. J. Organomet. Chem. 2022, 976, 122436,
DOI: doi.org/10.1016/j.jorganochem/2022.122436

Continuous Flow Technology as an Enabler for Innovative Transformations Exploiting Carbenes, Nitrenes, and Benzynes

Kian Donnelly and Marcus Baumann. J. Org. Chem. 2022, 87, 13, 8279–8288,
DOI: doi.org/10.1021/acs.joc.2c00963

Flow synthesis of oxadiazoles coupled with sequential in-line extraction and chromatography

Kian Donnelly and Marcus Baumann.
Beilstein J. Org. Chem. 2022, 18, 232–239,
DOI: doi.org/10.3762/bjoc.18.27

Protein domain-based prediction of drug/compound–target interactions and experimental validation on LIM kinases

Tunca Doğan, Ece Akhan Güzelcan, Marcus Baumann, Altay Koyas, Heval Atas, Ian R. Baxendale, Maria Martin, Rengul Cetin-Atalay.
PLoS Computational Biology 2021, 17, 11, DOI: doi.org/10.1371/journal.pcbi.1009171

Continuous Flow Synthesis of Anticancer Drugs

Mara Di Filippo and Marcus Baumann.
Molecules 2021, 26, 6992, DOI: doi.org/10.3390/molecules26226992

Synthesis of 2H-indazoles via the Cadogan reaction in batch and flow mode

Matilda Duffy, Mara Di Filippo and Marcus Baumann. Tetrahedron Lett., 2021, 86, 153522, DOI: 10.1016/j.tetlet.2021.153522

Interrupted Curtius Rearrangements of Quaternary Proline Derivatives: A Flow Route to Acyclic Ketones and Unsaturated Pyrrolidines

Marcus Baumann, Thomas S. Moody, Megan Smyth, and Scott Wharry. J. Org. Chem., 2021, 86, 20, 14199–14206, DOI: 10.1021/acs.joc.1c01133 

Highlighted by SynFacts: Synfacts 2021, 17, 1295

Scalability of photochemical reactions in continuous flow mode

Kian Donnelly and Marcus Baumann Journal of Flow Chemistry, 2021, 11, 223–241,
DOI: 10.1007/s41981-021-00168-z

Forgotten and forbidden chemical reactions revitalised through continuous flow technology

Arlene Bonner, Aisling Loftus, Alex C. Padgham and Marcus Baumann. Org. Biomol. Chem., 2021, 86, 20, 14199–14206 DOI: 10.1039/D1OB01452H

Discovery of a photochemical cascade process by flow-based interception of isomerising alkenes

Mara Di Filippo, Cristina Trujillo, Goar Sánchez-Sanz, Andrei S. Batsanov and Marcus Baumann. Chem. Sci., 2021, 12, 9895-9901, DOI:  10.1039/D1SC02879K  

A continuous flow synthesis of [1.1.1]propellane and bicyclo[1.1.1]pentane derivatives

Kian Donnelly and Marcus Baumann.
Chem. Commun., 2021, 57, 2871-2874 DOI: doi.org/10.1039/D0CC08124H

Highlighted by SynFacts: Synfacts 2021, 17, 0715

Coupling biocatalysis with high-energy flow reactions for the synthesis of carbamates and β-amino acid derivatives

Alexander Leslie, Thomas S. Moody, Megan Smyth, Scott Wharry and Marcus Baumann. Beilstein J. Org. Chem., 2021, 17, 379–384 
DOI:10.3762/bjoc.17.33, 

Development of a Continuous Photochemical Benzyne-Forming Process

Cormac Bracken, Andrei S. Batsanov and Marcus Baumann.
SynOpen, 2021, 5, 1, 29-35, DOI: 10.1055/s-0040-1706016

Continuous flow synthesis and antimicrobial evaluation of NHC* silver carboxylate derivatives of SBC3 in vitro and in vivo

Cillian O’Beirne, Magdalena E Piatek, Jen Fossen, Helge  Müller-Bunz, David R Andes, Kevin Kavanagh, Siddappa A Patil, Marcus Baumann and Matthias Tacke Metallomics, 2021, 2, 13, mfaa011,

DOI: 10.1093/mtomcs/mfaa011

Tandem Continuous Flow Curtius Rearrangement and Subsequent Enzyme-Mediated Impurity Tagging

Marcus Baumann, Alexander Leslie, Thomas S. Moody, Megan Smyth* and Scott Wharry.
Organic Process Research & Development, 2021, 25, 3, 452–456 DOI: doi.org/10.1021/acs.oprd.0c00420

Functional Group Interconversion Reactions in Continuous Flow Reactors 

Alexander Leslie, Angel Maria Joseph and Marcus Baumann*.
Current Organic Chemistry, 2021, 25, 19, 2217 – 2231, DOI: 10.2174/1385272825666210610154414 

A Scalable Continuous Photochemical Process for the Generation of Aminopropylsulfones

Mara Di Filippo, Stefano Bonciolini and Marcus Baumann.
Organic & Biomolecular Chemistry, 2020, 18, 9428-9432.
DOI: 10.1039/D0OB01801E

Overcoming the Hurdles and Challenges Associated with Developing Continuous Industrial Processes Marcus Baumann, Thomas S. Moody, Megan Smyth and Scott Wharry.
European Journal of Organic Chemistry, 2020, 48, 7398–7406, DOI: 10.1002/ejoc.202001278

Continuous Flow Synthesis of Quinolines via a Scalable Tandem Photoisomerization-Cyclization Process Mara Di Filippo and Marcus Baumann.
European Journal of Organic Chemistry, 2020, 39, 6199-6211, DOI: 10.1002/ejoc.202000957

Highlighted by SynFacts: Synfacts 2021, 17, 117

Continuous Flow Photochemistry For The Preparation Of Bioactive Molecules

Mara Di Filippo, Cormac Bracken and Marcus Baumann.
Molecules, 2020, 25, 356, DOI:10.3390/molecules25020356

A Perspective on Continuous Flow Chemistry in the Pharmaceutical Industry

Marcus Baumann, Thomas S. Moody, Megan Smyth and Scott Wharry.
Organic Process Research & Development, 2020, 24, 10, 1802–1813, DOI: doi.org/10.1021/acs.oprd.9b00524

Development of a continuous flow photoisomerization reaction converting isoxazoles into diverse oxazole products

Cormac Bracken and Marcus Baumann.
Journal of Organic Chemistry, 2020, 85, 4, 2607–2617, DOI: 10.1021/acs.joc.9b03399

Synthesis of Bioderived Cinnolines and Their Flow-Based Conversion into 1,4-Dihydrocinnoline Derivatives

Jonathan Devlin, Richard Clogher and Marcus Baumann.
Synlett, 2020, 31, 5, 487-491, DOI:10.1055/s-0039-1690752

Highlighted by SynFacts: Synfacts 2020, 16, 0241

Development of a telescoped flow process for the safe and effective generation of propargylic amines

Kian Donnelly, Huan Zhang and Marcus Baumann
Molecules, 2019, 24, 20, 3658, DOI: 10.3390/molecules24203658

Synthesis of new derivatives of boehmeriasin A and their biological evaluation in liver cancer

Ece Akhan Güzelcan, Ian R. Bazendale, Rengul Cetin-Atalay and Marcus Baumann.
European Journal of Medicinal Chemistry, 2019, 166, 243-255, DOI: 10.1016/j.ejmech.2019.01.056

Integrating reactive distillation with continuous flow processing

Marcus Baumann
Reaction Chemistry and Engineering, 2019, 4, 2, 368-371, DOI: 10.1039/c8re00217g

Integrating continuous flow synthesis with in-line analysis and data generation

Marcus Baumann
Organic and Biomolecular Chemistry, 2018, 16, 5946-5954, DOI: 10.1039/c8ob01437j